A Case of Methemoglobinemia Caused by Primaquine.
- Author:
Jae Yong LEE
1
;
Sung Han KIM
;
Sujong AN
;
Hye Seon OH
;
Sang Young YI
;
Hoon Hee LEE
;
Duck Jong HAN
Author Information
- Publication Type:Case Report
- Keywords: Methemoglobin; Methemoglobinemia; Primaquine
- MeSH: Adult; Clindamycin; Female; Heme; Humans; Kidney; Methemoglobin; Methemoglobinemia*; Plasmodium ovale; Plasmodium vivax; Pneumonia, Pneumocystis; Primaquine*
- From:Korean Journal of Medicine 2017;92(1):94-98
- CountryRepublic of Korea
- Language:Korean
- Abstract: Primaquine is often administered for the hypnozoite stage of Plasmodium vivax and Plasmodium ovale. Primaquine (with clindamycin) is also an alternative drug for treatment of pneumocystis pneumonia when trimethoprim/sulfamethoxazole cannot be used. Primaquine may cause methemoglobinemia, an altered state of hemoglobin in which the ferrous state of heme is oxidized to the ferric state. We report a case of methemoglobinemia caused by a standard dose of primaquine plus clindamycin in a 27-year-old female recipient of a kidney transplant who was diagnosed with pneumocystis pneumonia.
