Co-existent Mixed Connective Tissue Disease and Papillary Thyroid Cancer in a Patient with Primary Biliary Cirrhosis.
10.3904/kjm.2017.92.1.103
- Author:
Dong Wan KOO
1
;
Seung Geun LEE
;
Eun Kyoung PARK
;
Ji Heh PARK
;
Kyu Min LEE
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. sglee@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Mixed connective tissue disease;
Thyroid neoplasms;
Liver cirrhosis, Biliary;
Myositis
- MeSH:
Adult;
Arthralgia;
Autoimmune Diseases;
Azathioprine;
Female;
Humans;
Liver Cirrhosis, Biliary*;
Lupus Erythematosus, Systemic;
Mixed Connective Tissue Disease*;
Muscle Weakness;
Myositis;
Scleroderma, Systemic;
Skin;
Thyroid Gland*;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Medicine
2017;92(1):103-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 40-year-old female previously diagnosed with primary biliary cirrhosis was referred to the hospital complaining of muscle weakness, arthralgia, Raynaud's phenomenon, and thick skin. After work-up, she was diagnosed with both mixed connective tissue disease (MCTD) and papillary thyroid cancer (PTC), based on the Alarcon-Segovia criteria and pathological examination, respectively. High-dose glucocorticoid and azathioprine were introduced to treat active myositis of MCTD, and total thyroidectomy was performed to treat PTC. This report highlights the possible association between MCTD and thyroid cancer, and suggests that MCTD is associated with PTC, similar to other autoimmune diseases including Sjögren's syndrome, systemic sclerosis, and systemic lupus erythematosus.
