The Effect of Desmopressin in Nocturia.
- Author:
Dong Hwan LEE
1
;
Joon Chul KIM
;
Hong Jin SUH
;
Hyun Woo KIM
;
Tae Kon HWANG
Author Information
1. Department of Urology, college of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Nocturia;
Desmopressin
- MeSH:
Deamino Arginine Vasopressin*;
Humans;
Nocturia*;
Osmolar Concentration;
Quality of Life;
Specific Gravity
- From:Korean Journal of Urology
1999;40(5):613-616
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Nocturia results in sleep disturbance that may affect the quality of life during the day. We investigated the safety and efficacy of desmopressin in patients with nocturia without consideration of their underline diseases. MATERIALS AND METHODS: 30 patients who showed nocturia of 3 times or more per night were included in this study. All had failed to respond to treatment with regard to their underline disease and evening fluid restriction. Urinary specific gravity and osmolality, serum osmolality, BUN, Cr, Na, and K were monitored and voiding diary for 3 days was taken before and during treatment for 2 weeks. Meanwhile, patients whose nocturia were improved during treatment were asked whether symptom improvement continued or not after cessation. RESULTS: In 23(76.7%) out of 30 patients, desmopressin caused a significant decrease in nocturia without changing daytime frequency, laboratory data and serious adverse effects. After cessation of desmopressin, this effect continued in 11 patients(36.7%). CONCLUSIONS: Desmopressin seems to have a place in the treatment of nocturia, where more conventional therapies have failed.
