The Immunological Influences of Penile and Testicular Prosthesis on Human.
- Author:
Ja Hyeon KU
1
;
Nam Kyu LEE
;
Young Ho PARK
Author Information
1. Department of Urology, School of Medicine, Soonchunhyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Prosthesis;
Immunological alterations
- MeSH:
Antibodies, Antinuclear;
Blood Sedimentation;
Complement C3;
Complement C4;
Follow-Up Studies;
Humans*;
Immune System Diseases;
Immunoglobulin A;
Immunoglobulin E;
Immunoglobulin G;
Immunoglobulin M;
Immunoglobulins;
Medical Records;
Penile Prosthesis;
Physical Examination;
Postoperative Complications;
Prostheses and Implants*;
Reference Values;
Rheumatoid Factor;
Serologic Tests;
Silicone Gels
- From:Korean Journal of Urology
1999;40(5):628-633
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It has been recognized that silicone gel filled prosthesis has a possible hazard of immunological disease. We intended to analyze immunological alterations in recipients of silicone gel filled penile and testicular prosthesis. MATERIALS AND METHODS: Medical records of 14 patients who underwent penile prosthesis insertion and 24 patients who underwent testicular prosthesis insertion were reviewed. Of 38 recipients, 8 patients with penile prosthesis and 15 patients with testicular prosthsis were examined by symptom, physical examination and serologic tests. Serologic tests included erythrocyte sedimentation rate, rheumatoid factor, antinuclear antibody, complement 3, complement 4, immunoglobulin A, immunoglbulin E, immunoglobulin G, and immunoglobulin M. RESULTS: Of 38 patients who underwent prosthesis, there were postoperative complications in 6 patients. Of 23 patients who were examined by symptom, physical examination and serologic tests, 1 patients have intermittent testicular pain and all the patient were normal on physical examination. Of 8 patients who underwent penile prosthesis insertion, the abnormality rates of serologic tests were 25.0% in erythrocyte sedimentation rate, 12.5% in rheumatoid factor, 25.0% in increased complement 3, 12.5% in complement 4, 50.0% in immunoglobulin E, and 12.5% in immunoglobulin G. Antineuclear antibody was weakly reactive at 1:40 titer in 2 patients(25.0%), but these results were within normal range, and immunoglobulin G and immunoglobulin M were normal in all the patients. Of 15 patients who underwent testicular prosthesis insertion, the abnormality rates of serologic tests were 13.3% in erythrocyte sedimentation rate, 60..0% in complememt 3, 20.0% in complement 4, 13.3% in immunoglobulin A, 100.0% in immunoglobulin E, and 66.7% in immunoglobulin G. And rheumatoid factor, antineuclear antibody, and immunoglobulin M were normal in all the patients. There were no patients with the diagnostic criteria of immunological disease. CONCLUSIONS: There were no patients that were included in diagnostic criteria of immunological diseases in our results and it is suggested that silicone gel filled prosthesis have no hazard of immunological disease. However, because serologic tests were abnormal in some patients, we suggest that careful followup of recipients of silicone gel filled prosthesis is needed.
