Usefulness of Urinary Trypsinogen-2 Dipstick Test for Diagnosis of Acute Pancreatitis.
- Author:
Seoung Joon HWANG
1
;
Jun Pyo CHUNG
;
Young Gyun KIM
;
Dae Hoon SONG
;
Jae Sung LEE
;
Seung Seok BAEK
;
Do Yun KIM
;
Dok Yong LEE
;
Yon Soo JEONG
;
Sang Won JI
;
Se Joon LEE
;
Si Young SONG
;
Kwan Sik LEE
;
Jae Bock CHUNG
;
Sang In LEE
;
Jin Kyung KANG
;
Jun Seog PARK
;
Kwang Hyun CHO
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. chungjp@yumc.yonsei.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Pancreatitis;
acute;
Urinary trypsinogen-2;
Dipstick test
- MeSH:
Acute Disease;
Adult;
Aged;
Biological Markers/analysis;
English Abstract;
Female;
Humans;
Lipase/blood;
Male;
Middle Aged;
Pancreatitis/*diagnosis;
Reagent Strips;
Sensitivity and Specificity;
Trypsinogen/*urine
- From:The Korean Journal of Gastroenterology
2004;43(6):364-369
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis. METHODS: Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls. RESULTS: On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992. CONCLUSIONS: Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity.
