A Case of Rifampicin associated Pseudomembranous Colitis.
- Author:
Jae Hi KIM
1
;
Jin Hyung PARK
Author Information
1. Department of Internal Medicine, Pochon CHA University College of Medicine, Korea. Phalsue@hanmail.net
- Publication Type:Case Report ; English Abstract
- Keywords:
Pseudomembranous colitis;
Rifampicin
- MeSH:
Antibiotics, Antitubercular/*adverse effects;
English Abstract;
Enterocolitis, Pseudomembranous/*chemically induced/diagnosis/drug therapy;
Female;
Humans;
Middle Aged;
Rifampin/*adverse effects;
Tuberculosis, Pulmonary/drug therapy
- From:The Korean Journal of Gastroenterology
2004;43(6):376-379
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pseudomembranous colitis is a dangerous but unusual side effect of antibiotics usage. We report a case of pseudomembranous colitis that developed in a 50-year-old female patient with diabetes mellitus during first line anti-tuberculous therapy including rifampicin. The patient was diagnosed with active pulmonary tuberculosis 70 days earlier. On admission, she suffered intermittent abdominal pain and watery diarrhea for 2 weeks. Colonoscopy revealed exudative, punctuate, raised plaques with skip areas or edematous hyperemic mucosa, and histopathologic findings were consistent with pseudomembranous colitis with typical volcano-like exudate. Symptoms improved on treatment with metronidazole. There was no recurrence after reinstitution of the anti-tuberculous agents excluding rifampicin. In patients with persistent diarrhea receiving anti-tuberculosis treatment, rifampicin associated pseudomembranous colitis should always be kept in mind.
