Influence of the Host Factors on Human Papillomavirus Infection and Vaccine Efficacy.
10.4167/jbv.2015.45.3.179
- Author:
Sung Hwa SOHN
1
;
Jae Hwan NAM
Author Information
1. Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Korea. jhnam@catholic.ac.kr
- Publication Type:Review
- Keywords:
HPV;
Vaccine efficacy;
Probiotics;
Microbiota
- MeSH:
Condylomata Acuminata;
Diagnosis;
Head and Neck Neoplasms;
Humans*;
Immune System;
Microbiota;
Papilloma;
Papillomavirus Infections*;
Papillomavirus Vaccines;
Probiotics;
Uterine Cervical Neoplasms
- From:Journal of Bacteriology and Virology
2015;45(3):179-188
- CountryRepublic of Korea
- Language:English
-
Abstract:
Human papillomavirus (HPV) is associated with cervical cell changes, genital warts, recurrent respiratory papillomatosis, laryngeal papillomatosis, head and neck cancer, and cervical cancer. Two commercial HPV vaccines have successfully been made available in the clinical field. This review covers the progress of cervical disease by understanding the nature of HPV infection, as well as the relationship between the host factors and HPV vaccine effectiveness. Among these host factors, microbiota has been revealed to influence the development and function of both the innate and adaptive immune systems. Therefore, the composition of the microbiome may ultimately affect vaccine efficacy. Understating the relationship between host factors and HPV infection/vaccine efficacy may prove to be useful in earlier diagnosis, as well as disease prophylaxis.
