Ibuprofen Associated Acute Vanishing Bile Duct Syndrome and Toxic Epidermal Necrolysis in an Infant.
10.3349/ymj.2014.55.3.834
- Author:
Hye Young KIM
1
;
Hea Kyoung YANG
;
Seong Heon KIM
;
Jae Hong PARK
Author Information
1. Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. jhongpark@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Acute vanishing bile duct syndrome;
toxic epidermal necrolysis;
infant
- MeSH:
Female;
Humans;
Ibuprofen/*adverse effects;
Infant;
Stevens-Johnson Syndrome/*diagnosis/*etiology
- From:Yonsei Medical Journal
2014;55(3):834-837
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced. Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis have not been reported previously in infants. We report a 7-month-old infant with ibuprofen associated toxic epidermal necrolysis, followed by severe and rapidly progressive vanishing bile duct syndrome. She recovered totally with supportive care.
