Clinicopathological Significance of Invasive Ductal Carcinoma with High Prevalence of CD44(+)/CD24(-/low) Tumor Cells in Breast Cancer.
- Author:
Ji Youn SUNG
1
;
Gou Young KIM
;
Yong Koo PARK
;
Juhie LEE
;
Youn Wha KIM
;
Sung Jig LIM
Author Information
1. Department of Pathology, Kyung Hee University Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Neoplastic stem cells;
CD44 protein, human;
CD24 protein, human;
Invasive ductal carcinoma;
Carcinoma, intraductal, noninfiltrating
- MeSH:
Antigens, CD24;
Antigens, CD44;
Biology;
Breast;
Breast Neoplasms;
Carcinoma, Ductal;
Carcinoma, Intraductal, Noninfiltrating;
Estrogens;
Immunohistochemistry;
Neoplasm Metastasis;
Neoplastic Stem Cells;
Prevalence
- From:Korean Journal of Pathology
2010;44(4):390-396
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Epithelial tumor cells with a CD44(+)/CD24(-/low) immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance. METHODS: The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44(+)/CD24(-/low) tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed. RESULTS: IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44(+)/CD24(-/low) tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44(+)/CD24(-/low) tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001). CONCLUSIONS: IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44(+)/CD24(-/low) tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
