Exuberant Smooth Muscle Cells in Fibroadenoma of the Breast: A Case Report.
- Author:
Ga Eon KIM
1
;
Young KIM
;
Eun Hui JEONG
;
Jo Heon KIM
;
Min Ho PARK
;
Ji Shin LEE
Author Information
1. Department of Pathology, Chonnam National University Medical School, Gwangju, Korea. jshinlee@hanmail.net
- Publication Type:Case Report
- Keywords:
Breast;
Fibroadenoma;
Muscle cells;
Metaplasia
- MeSH:
Actins;
Aged;
Breast;
Calcium-Binding Proteins;
Cytoplasm;
Desmin;
Eosinophils;
Estrogens;
Female;
Fibroadenoma;
Humans;
Keratins;
Metaplasia;
Microfilament Proteins;
Muscle Cells;
Muscle, Smooth;
Myocytes, Smooth Muscle;
Receptors, Progesterone;
S100 Proteins;
Stromal Cells
- From:Korean Journal of Pathology
2010;44(4):431-434
- CountryRepublic of Korea
- Language:English
-
Abstract:
Smooth muscle cell metaplasia is an extremely rare form of stromal differentiation in fibroadenomas. We describe a case of fibroadenoma with exuberant smooth muscle cells in a 72-year-old woman. The mass was located in the upper central portion of the left breast. It was well circumscribed and its greatest dimension was 3 cm. Histologically, the glandular elements resembled the appearance of fibroadenoma, but the stromal elements were composed of spindle cell bundles with abundant eosinophilic cytoplasm and elongated cigar-shaped nuclei. Neither mitotic activity nor cellular atypia was seen. The stromal cells were immunohistochemically positive for smooth muscle actin, calponin, desmin, and estrogen receptor-beta, but negative for CD34, S-100 protein, p63, CD10, estrogen receptor-alpha, progesterone receptor and cytokeratin. These results proved that the stromal cells showed features of smooth muscle cells.
