Immunogenicity and Safety of Diphtheria-tetanus Vaccine in Adults.
10.3346/jkms.2010.25.12.1727
- Author:
Jung Hyun CHOI
1
;
Eun Ju CHOO
;
Aejung HUH
;
Su Mi CHOI
;
Joong Sik EOM
;
Jin Seo LEE
;
Sun Hee PARK
;
Jin Han KANG
Author Information
1. Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article ; Clinical Trial, Phase IV ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Diphtheria;
Tetanus;
Vaccines;
Immunogenicity;
Safety;
Adult
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antibodies, Bacterial/blood;
Diphtheria/prevention & control;
Diphtheria-Tetanus Vaccine/*adverse effects/*immunology;
Female;
Humans;
Immunization, Secondary;
Male;
Middle Aged;
Tetanus/prevention & control;
Tetanus Toxoid/immunology
- From:Journal of Korean Medical Science
2010;25(12):1727-1732
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level (<0.1 U/mL). After the first dose of Td vaccine, 92.6% and 77.6% of subjects gained protective antibody concentrations (> or =0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.
