Ketonuria after Fasting may be Related to the Metabolic Superiority.
10.3346/jkms.2010.25.12.1771
- Author:
Nam Seok JOO
1
;
Duck Joo LEE
;
Kwang Min KIM
;
Bom Taeck KIM
;
Chan Won KIM
;
Kyu Nam KIM
;
Sang Man KIM
Author Information
1. Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
Urine Ketone;
Lipolysis;
Metabolic Syndrome;
Korean
- MeSH:
Blood Glucose/analysis;
Blood Pressure;
Body Weight;
Cross-Sectional Studies;
*Fasting;
Female;
Humans;
Insulin/blood;
Ketosis/*complications/diagnosis;
Lipoproteins, HDL/blood;
Male;
Metabolic Syndrome X/*complications/epidemiology;
Obesity/complications/epidemiology;
Odds Ratio;
Time Factors;
Triglycerides/blood;
Waist Circumference
- From:Journal of Korean Medical Science
2010;25(12):1771-1776
- CountryRepublic of Korea
- Language:English
-
Abstract:
Obese individuals are less able to oxidize fat than non-obese individuals. Caloric reduction or fasting can detect ketonuria. We investigated the differences of metabolic parameters in the presence of ketonuria after a minimum 8 hr fast in a cross-sectional analysis of 16,523 Koreans (6,512 women and 10,011 men). The relationship between the presence of ketonuria of all subjects and prevalence of obesity, central obesity, metabolic syndrome, and obesity-related metabolic parameters were assessed. The ketonuria group had lower prevalence of obesity, central obesity, and metabolic syndrome than the non-ketonuria group. In addition, all metabolic parameters (including body weight, waist circumference, blood glucose, high-density lipoprotein, triglyceride, blood pressure, and insulin) were favorable in the ketonuria group than in the non-ketonuria group, even after adjustment for age, tobacco use, and alcohol consumption. The odds ratios of having obesity (odds ratio [OR]=1.427 in women, OR=1.582 in men, P<0.05), central obesity (OR=1.675 in women, OR=1.889 in men, P<0.05), and metabolic syndrome (OR=3.505 in women, OR=1.356 in men, P<0.05) were increased in the non-ketonuria group compared to the ketonuria group. The presence of ketonuria after at least an 8 hr fast may be indicative of metabolic superiority.
