Changes of Serum Androgen and Bone Mineral Density in Korean Aging Male.
- Author:
Doo Sang KIM
;
Young Ho KIM
;
Nam Kyu LEE
- Publication Type:Original Article
- Keywords:
Aging;
Male;
Androgen;
Bone mineral density;
Osteoporosis
- MeSH:
Absorptiometry, Photon;
Aged;
Aging*;
Bone Density*;
Diagnosis;
Female;
Femur;
Femur Neck;
Gonadal Steroid Hormones;
Humans;
Male*;
Osteoporosis;
Prolactin;
Testosterone
- From:Korean Journal of Urology
2001;42(9):971-977
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Osteoporosis is generally regarded as disease of women and there are extensive data about post-menopausal osteopotosis, but there is relatively little information concerning the osteoporosis in aging male. We aimed to determine the relationships between age ,androgen and bone mineral density (BMD) in elderly korean men. MATERIALS AND METHODS: We evaluated the sex hormones and BMD of 82 elderly men between May 1999 and April 2000. Serum free testosterone (FT), total testosterone (TT), DHT, LH, FSH and Prolactin were measured by RIA. BMD at anteroposterior L2-4, femoral neck, ward's triangle, femoral trochanter and femoral shaft were determined by dual-energy X-ray absorptiometry. We defined group I as free testosterone <10ng/dl and group II as 10ng/dl. RESULTS: Serum LH and FSH increased with age. There was a significant decrease in serum FT with age, but T concentrations remained unchanged. There were significant declines with age in BMD at femoral neck, Ward's triangle, femoral trochanter, femoral shaft. Serum FT were significantly correlated to BMD at anteroposterior L2-4, femoral neck, Ward's triangle, femoral trochanter, femoral shaft. After controlling for age, serum FT were significantly correlated to BMD at femoral trochanter, femoral shaft. Mean BMD was significantly lower in group I than group II at anteroposterior L2-4, femoral shaft. CONCLUSIONS: We suggest that FT is a male osteoporotic marker in man older than 50 years and bone mineral density should be considered for diagnosis of male osteoporosis associated with PADAM, especially when FT is lower than 10ng/dl.
