The Relationship between Reduced Lung Function and High Sensitive C-reactive Protein in Healthy Adult Men.
- Author:
Jung Un LEE
1
;
Yu Jin PAEK
Author Information
1. Department of Family Medicine, Wonkwang University Sanbon Hospital, Sanbon, Korea.
- Publication Type:Original Article
- Keywords:
high sensitive C-reactive protein;
forced expiratory volume;
respiratory function tests;
systemic inflammation;
male
- MeSH:
Adult*;
C-Reactive Protein*;
Confounding Factors (Epidemiology);
Cross-Sectional Studies;
Forced Expiratory Volume;
Glucose;
Health Promotion;
Humans;
Inflammation;
Lung Diseases;
Lung*;
Male;
Odds Ratio;
Reference Values;
Respiratory Function Tests;
Smoke;
Smoking;
Triglycerides;
Waist Circumference;
Young Adult
- From:Journal of the Korean Academy of Family Medicine
2007;28(11):860-866
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function with obstructive and restrictive lung diseases. We hypothesized that forced expiratory volume in 1 second (FEV(1)) within the normal range is inversely associated with high sensitive C-reactive protein (hs-CRP), as a marker of chronic inflammation in healthy Korean adult men. METHODS: We analyzed the association of hs-CRP with pulmonary function test including FEV(1), components of metabolic syndrome among male participants (n=3,736), more than 20 years old who had visited a health promotion center at a university hospital between January and December, 2006. RESULTS: In this cross-sectional study, there was an inverse association between hs-CRP levels and quartiles of FEV(1) (P for trend<0.0001) after adjusting for age, smoking status, waist circumference, glucose, triglyceride, and HDL-cholesterol. A similar association was present in non-smoking subjects, but there was no significant trend (P for trend=0.115) whereas it was significant in smoking subjects (P for trend<0.0001), and in ex-smoking subjects (P for trend=0.006). The odds ratios of having elevated hs-CRP (>2.2 mg/L) across FEV(1) quartiles, with the lowest quartile (Q1) as the reference group was 1.01 (0.75~1.35) in Q2, 1.24 (0.93~1.65) in Q3, 1.52 (1.15~2.01) in Q4 after adjusting for the confounding variables. CONCLUSION: The decline of FEV(1) within the normal range was inversely associated with low grade inflammation as measured by hs-CRP. This result showed that systemic inflammation may be linked to early impaired pulmonary function in healthy adult men.
