Effects of Topical Tranilast on Corneal Haze with the Pentacam(R) after Photorefractive Keratectomy.
10.3341/jkos.2014.55.9.1277
- Author:
Sung In KIM
1
;
Tae Hoon OH
Author Information
1. Department of Ophthalmology, Saevit Eye Hospital, Goyang, Korea. 76drhoon@hanmail.net
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Corneal haze;
Pentacam(R);
PRK;
Tranilast
- MeSH:
Corneal Opacity;
Humans;
Photorefractive Keratectomy*;
Prospective Studies;
Radius
- From:Journal of the Korean Ophthalmological Society
2014;55(9):1277-1283
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam(R) after photorefractive keratectomy (PRK). METHODS: A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes <-5 D and > or =-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam(R) and compared between the 2 groups. RESULTS: Statistical differences were not found in preoperative data in the tranilast or control groups (all P > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (P < 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group (P > 0.05). CONCLUSIONS: The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam(R) can provide a useful objective measure of corneal haze.
