Comparison of Retinal Nerve Fiber Layers in Patients with Non-Neovascular Age-Related Macular Degeneration and Normal Controls.
10.3341/jkos.2014.55.9.1334
- Author:
Jae Young KIM
1
;
Hyewon CHUNG
;
Hyung Chan KIM
Author Information
1. Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. eyekim@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Non-neovascular age-related macular degeneration;
Retinal nerve fiber layer thickness;
Spectral domain optical coherence tomography
- MeSH:
Geographic Atrophy;
Humans;
Intraocular Pressure;
Macular Degeneration*;
Nerve Fibers*;
Retinaldehyde*;
Tomography, Optical Coherence;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2014;55(9):1334-1339
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In neovascular age-related macular degeneration (AMD), it is reported that retinal nerve fiber layer (RNFL) thickness becomes gradually thinner due to degeneration of the outer retinal layer. To our knowledge, there is no previous report regarding RNFL thickness in patients with non-neovascular AMD. Therefore, in this study, we compared RNFL thickness in patients with non-neovascular AMD and normal controls. METHODS: Thirty-one eyes with AMD category 3a (AREDS research group), 11 eyes suffering foveal geographic atrophy AMD category 4a, and 31 age-matched normal eyes were evaluated. In every group, regional RNFL thickness (General, Temporal, Superotemporal, Superonasal, Superior, Nasal, Inferonasal, Inferotemporal, and Inferior) was measured using spectral domain optical coherence tomography (SD-OCT). RESULTS: There were no significant differences in age or intraocular pressure among the 3 groups. The mean best corrected visual acuity (BCVA) (log MAR) of the category 4a group was significantly decreased compared to those of the other 2 groups. The mean RNFL thickness in total area in the category 3a group, category 4a group, and normal control group was 99.5 +/- 14.0 microm, 99.3 +/- 9.4 microm, and 99.4 +/- 9.6 microm, respectively. The difference was not statistically significant. No other regional mean values of RNFL thickness in the three groups were significantly different. CONCLUSIONS: There was no significant difference in RNFL thickness between non-neovascular patients and the control group.
