The Effects of Commodified Growth Factor Products on the Fibrovascularization of Porous Polyethylene Orbital Implants.
10.3341/jkos.2014.55.9.1366
- Author:
Won Mo GU
1
;
Joon Hyuk CHOI
;
Jun Hyuk SON
Author Information
1. Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. sjh@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Basic fibroblast growth factor;
Epidermal growth factor;
Fibrovascularization;
Porous polyethylene orbital implant
- MeSH:
Epidermal Growth Factor;
Fibroblast Growth Factor 2;
Orbital Implants*;
Plastics;
Polyethylene*;
Rats, Sprague-Dawley
- From:Journal of the Korean Ophthalmological Society
2014;55(9):1366-1371
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the effects of commodified growth factor products used clinically on fibrovascular ingrowth into porous polyethylene orbital implants. METHODS: Porous polyethylene orbital implant sheets (Medpor(R)) soaked with Nepidermin (Easyef(R)), Trafermin (Fiblast(R)), and normal saline were implanted into the backs of 18 Sprague-Dawley rats. The degree of fibrovascular ingrowth as observed using a light microscope was compared 1 and 2 weeks after implantation and was calculated as a percentage of the fibrovascular ingrowth length. RESULTS: One week after implantation, the percentage of fibrovascular ingrowth length was 25.33 +/- 5.43%, 22.56 +/- 5.30%, and 21.78 +/- 4.66% in the Easyef(R)-, Fiblast(R)- and normal saline-soaked groups. The degree of fibrovascularization was higher in the Easyef(R)-soaked group than in the other groups (p = 0.020, 0.012). Two weeks after implantation, the degree of fibrovascularization was 98.33 +/- 5.00%, 100.00 +/- 0.00%, and 95.89 +/- 4.57%, which was significantly higher in the Easyef(R)-, and Fiblast(R)-soaked groups than in normal saline-soaked group (p = 0.019, <0.001). CONCLUSIONS: Commodified growth factor products used in other areas selectively enhanced fibrovascular ingrowth to a greater degree and earlier in ophthalmic plastic and reconstructive surgery.
