PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
- Author:
Jia Hao FAN
1
;
Ming Que XIANG
;
Qing Ling LI
;
Hong Tao SHI
;
Jin Jun GUO
Author Information
1. Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. guojinjun1972@163.com
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Patatin-like phospholipase domain containing protein 3 rs738409;
Advanced liver fibrosis;
Fatty liver;
Hepatitis C, chronic;
Meta-analysis
- MeSH:
Asian Continental Ancestry Group;
Consensus;
Fatty Liver;
Fibrosis*;
Hepatitis C, Chronic*;
Hepatitis, Chronic*;
Humans;
Liver Cirrhosis;
Odds Ratio;
Phospholipases;
Publication Bias
- From:Gut and Liver
2016;10(3):456-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The recognition of a correlation between patatin-like phospholipase domain containing-protein 3 (PNPLA3) rs738409 (C>G) and the severity of liver steatosis or fibrosis in chronic hepatitis C (CHC) has not reached a consensus. This meta-analysis sought to investigate with accuracy the association between the PNPLA3 rs738409 (C>G) polymorphism and liver steatosis and advanced fibrosis in CHC patients. METHODS: We performed a comprehensive literature search from the PubMed, Embase, Web of Science, and Google Scholar databases up to December 31, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using Stata 12.0 software. RESULTS: The meta-analysis revealed the severity of liver fibrosis was significantly higher in CHC patients with PNPLA3 rs738409 GG in Caucasians (versus CC+CG: OR, 2.29; 95% CI, 1.57 to 3.35; p<0.05) but not Asian populations. In Caucasians, liver steatosis was also more severe in CHC patients with rs738409 GG (versus CC+CG; OR, 4.33; 95% CI, 2.59 to 7.22; p<0.05). The sensitivity analysis indicated the results of this meta-analysis were stable and no publication bias was detected. CONCLUSIONS: PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations.
