Lymphomatoid Granulomatosis: CT and FDG-PET Findings.
10.3348/kjr.2011.12.6.671
- Author:
Jonathan H CHUNG
1
;
Carol C WU
;
Matthew D GILMAN
;
Edwin L PALMER
;
Robert P HASSERJIAN
;
Jo Anne SHEPARD
Author Information
1. Institute of Advanced Biomedical Imaging, National Jewish Health, Denver, CO 80206, USA. chungj@njhealth.org
- Publication Type:Original Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
- Keywords:
Lymphomatoid granulomatosis;
Cavitation;
Pulmonary nodules;
Pulmonary masses;
Halo sign;
Air-bronchogram sign
- MeSH:
Adult;
Biopsy, Needle;
Fluorodeoxyglucose F18/*diagnostic use;
Humans;
Lung Neoplasms/pathology/*radiography/*radionuclide imaging;
Lymphomatoid Granulomatosis/pathology/*radiography/*radionuclide imaging;
Male;
Middle Aged;
*Positron-Emission Tomography;
Radiopharmaceuticals/*diagnostic use;
*Tomography, X-Ray Computed
- From:Korean Journal of Radiology
2011;12(6):671-678
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Lymphomatoid granulomatosis (LG) is a rare, aggressive extranodal Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. The purpose of our study was to analyze the CT and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of pulmonary LG. MATERIALS AND METHODS: Between 2000 and 2009, four patients with pathologically proven pulmonary LG and chest CT were identified. Two of these patients also had FDG-PET. Imaging features of LG on CT and PET were reviewed. RESULTS: Pulmonary nodules or masses with peribronchovascular, subpleural, and lower lung zonal preponderance were present in all patients. Central low attenuation (4 of 4 patients), ground-glass halo (3 of 4 patients), and peripheral enhancement (4 of 4 patients) were observed in these nodules and masses. An air-bronchogram and cavitation were seen in three of four patients. FDG-PET scans demonstrated avid FDG uptake in the pulmonary nodules and masses. CONCLUSION: Pulmonary LG presents with nodules and masses with a lymphatic distribution, as would be expected for a lymphoproliferative disease. However, central low attenuation, ground-glass halo and peripheral enhancement of the nodules/masses are likely related to the angioinvasive nature of this disease. Peripheral enhancement and ground-glass halo, in particular, are valuable characteristic not previously reported that can help radiologists suggest the diagnosis of pulmonary LG.
