A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report.
10.5125/jkaoms.2017.43.4.272
- Author:
Massimo VIVIANO
1
;
Alessandra ADDAMO
;
Serena COCCA
Author Information
1. Department of Medical Biotechnologies, Dentistry Clinic, University of Siena, Siena, Italy.
- Publication Type:Case Report
- Keywords:
Bisphosphonate-associated osteonecrosis of the jaw;
Sepsis;
Necrotizing fasciitis;
Jaw fractures
- MeSH:
Bisphosphonate-Associated Osteonecrosis of the Jaw*;
Bone Resorption;
Diphosphonates;
Fasciitis, Necrotizing;
Hypercalcemia;
Inflammation;
Jaw Fractures;
Mandible;
Multiple Myeloma;
Osteolysis;
Osteoporosis;
Sepsis;
Shock, Septic
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2017;43(4):272-275
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
