Effect of an L- and T-Type Calcium Channel Blocker on 24-Hour Systolic Blood Pressure and Heart Rate in Hypertensive Patients.
10.4070/kcj.2012.42.4.231
- Author:
Masae KOMUKAI
1
;
Takeshi TSUTSUMI
;
Mio EBADO
;
Youichi TAKEYAMA
Author Information
1. Division of Cardiology, Showa University Fujigaoka Hospital, Yokohama, Japan. maco21011969@gmail.com
- Publication Type:Original Article
- Keywords:
Blood pressure;
Calcium channel blockers;
Heart rate;
Hypertension
- MeSH:
Blood Pressure;
Calcium Channel Blockers;
Calcium Channels, T-Type;
Dihydropyridines;
Heart;
Heart Rate;
Humans;
Hypertension;
Nitrophenols;
Organophosphorus Compounds
- From:Korean Circulation Journal
2012;42(4):231-238
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the effects of an L- and T-type calcium channel blocker (CCB) on 24-hour systolic blood pressure (24-hour SBP) and heart rate (24-hour HR) profiles in essential hypertensive patients. SUBJECTS AND METHODS: Thirty-seven consecutive patients were enrolled in this study. The 24-hour SBP and HR were recorded before and after treatment with efonidipine (L- and T-type CCB, 40 mg), after waking. Changes in 24-hour SBP and HR and the diurnal to nocturnal SBP ratio were measured. The best-fit curves of changes in SBP and HR were depicted using a periodic function. RESULTS: The mean 24-hour SBP and HR decreased significantly after treatment. The diurnal to nocturnal SBP ratio in dipper-type hypertension cases decreased from 16.7+/-6.1% to 8.3+/-9.8% (p<0.05), whereas in non-dipper hypertension cases, it increased from 2.3+/-2.9% to 7.7+/-5.1% (p<0.01). The antihypertensive effect was minimal at 5.0 hours after drug administration and it slowly recovered at a constant rate (2.1 mm Hg/h) over 12 hours in dipper cases. The median 24-hour changes in HR in the dipper and non-dipper cases were -2.3/min and -5.4/min, respectively. A continuous reduction in the change in HR was seen from 3.5 to 23 hours after drug administration. CONCLUSION: The antihypertensive action of efonidipine was characterized by a slow recovery of the SBP decrease at a constant rate (2.1 mm Hg/h) and a non-administration time dependent reduction in 24-hour HR.
