The Etiologic Agents and Clinical Outcomes of Adult Community-acquired Pneumonia in Jeju.
10.4046/trd.2009.66.5.358
- Author:
Bong Hee JEON
1
;
Miok KIM
;
Jeong Hong KIM
;
Sang Yop SHIN
;
Jaechun LEE
Author Information
1. School of Medicine, Jeju National University, Jeju, Korea.
- Publication Type:Original Article
- Keywords:
Pneumonia;
Drug resistance;
Community-acquired infections
- MeSH:
Adult;
Ceftriaxone;
Chlamydophila;
Clarithromycin;
Community-Acquired Infections;
Drug Resistance;
Drug Resistance, Microbial;
Erythromycin;
Female;
Humans;
Korea;
Legionella;
Mycoplasma;
Ofloxacin;
Penicillins;
Pleural Effusion;
Pneumonia;
Prospective Studies;
Referral and Consultation;
Sputum;
Streptococcus pneumoniae;
Treatment Failure
- From:Tuberculosis and Respiratory Diseases
2009;66(5):358-364
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The appropriate empirical antimicrobial choice in the treatment of community-acquired pneumonia (CAP) should be advocated by community-based information on the etiologic pathogens, their susceptibility to antimicrobials, clinical characteristics and outcomes. Jeju is a geographically isolated and identical region in Korea. However, there is no regional reference on adult CAP available. This study investigated the etiologic agents and clinical outcomes of adult patients diagnosed with CAP in Jeju, Korea, to help guide the empirical antimicrobial choice. METHODS: A prospective observational study for one year in a referral hospital in Jeju, Korea. Patients diagnosed with CAP were enrolled with their clinical characteristics. Microbiological evaluations to identify the etiologic agents in the adult patients with CAP were performed with blood culture, expectorated sputum smear and culture, antibody tests for mycoplasma, chlamydophila, and antigen tests for legionella and pneumococcus. The clinical outcomes of the initial empirical treatment were analyzed. RESULTS: Two hundred and three patients with mean age of 64 and 79 females were enrolled. Ten microbials from 90 cases (44.3%) were isolated and multiple isolates were confirmed in 30. Among the microbial isolates, S. pneumoniae (36.3%) was the most common, followed by M. pneumoniae (23.0%), C. pneumoniae (17.0%), S. aureus (9.6%) and P. aeruginosa (5.9%). The initial treatment failure (23.8%) was related to the isolation of polymicrobial pathogens, elevated inflammatory markers, and the presence of pleural effusion. Among the 30 isolates of S. pneumoniae, 16 (53.3%) were not susceptible to penicillin, and 19 isolates (63.3%) to erythromycin and clarithromycin. However, 29 isolates (96.7%) were susceptible to levofloxacin and ceftriaxone. CONCLUSION:S. pneumoniae, M. pneumoniae, S. aureus, and P. aeruginosa are frequent etiologic agents of adult CAP in Jeju, Korea. The clinical characteristics and antibiotic resistance should be considered when determining the initial empirical antimicrobial choice. Respiratory quinolone or ceftriaxone is recommended as an empirical antimicrobiotic in the treatment of adult CAP in Jeju, Korea.
