Antibiotic susceptibility and imaging findings of the causative microorganisms responsible for acute urinary tract infection in children: a five-year single center study.
- Author:
Ji Eun YOON
1
;
Wun Kon KIM
;
Jin Seok LEE
;
Kyeong Seob SHIN
;
Tae Sun HA
Author Information
- Publication Type:Original Article
- Keywords: Urinary tract infection; Escherichia coli; Antimicrobial susceptibility
- MeSH: Amikacin; Ampicillin; Aztreonam; Ceftriaxone; Cephalosporins; Child; Enterobacter; Escherichia coli; Gentamicins; Humans; Imipenem; Klebsiella pneumoniae; Korea; Pediatrics; Proteus; Retrospective Studies; Urinary Tract; Urinary Tract Infections
- From:Korean Journal of Pediatrics 2011;54(2):79-85
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: We studied the differences in the antibiotic susceptibilities of the microorganisms that causeing urinary tract infections (UTI) in children to obtain useful information on appropriate drug selection for childhood UTI. METHODS: We retrospectively analyzed the antibiotic susceptibilities of 429 microorganisms isolated from 900 patients diagnosed with UTI in the Department of Pediatrics, Chungbuk National University Hospital, from 2003 to 2008. RESULTS: The most common causative microorganisms for UTI were Escherichia coli (81.4%), Klebsiella pneumoniae (8.4%), Enterobacter spp. (1.7%), and Proteus spp. (0.4%). E. coli showed relatively high susceptibility as compared to imipenem (100%), amikacin (97.7%), aztreonam (97.9%), cefepime (97.7%), and ceftriaxone (97.1%), while it showed relatively low susceptibility to gentamicin (GM) (79.0%), trimethoprim/sulfamethoxazole (TMP/SMX) (68.7%), ampicillin/sulbactam (33.0%), and ampicillin (AMP) (28.6%). There were no significant differences in the image findings for causative microorganisms. CONCLUSION: Gram-negative organisms showed high susceptibility to amikacin and third-generation cephalosporins, and low susceptibility to AMP, GM, and TMP/SMX. Therefore, the use of AMP or TMP/SMX as the first choice in empirical and prophylactic treatment of childhood UTI in Korea should be reconsidered and investigated further.
