Sweet's syndrome: a cutaneous harbinger of ovarian carcinoma.
10.3802/jgo.2012.23.4.288
- Author:
Amanda Nickles FADER
1
;
Abigail Duncan WINDER
;
Samith SANDADI
;
Robert DEBERNARDO
Author Information
1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Greater Baltimore Medical Center/Johns Hopkins Hospital, Baltimore, MD, USA. amandanfader@gmail.com
- Publication Type:Case Report
- Keywords:
Cutaneous rash;
Neutrophilia;
Ovarian neoplasms;
Paraneoplastic syndrome;
Sweet's syndrome
- MeSH:
Biopsy;
Carcinoma;
Exanthema;
Extremities;
Female;
Fever;
Humans;
Middle Aged;
Neutrophils;
Ovarian Neoplasms;
Paraneoplastic Syndromes;
Skin;
Sweet Syndrome
- From:Journal of Gynecologic Oncology
2012;23(4):288-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a condition characterized by fever, neutrophilia, erythematous skin lesions, and a dermal infiltrate consisting predominantly of mature neutrophils on histology. Sweet's syndrome is a reactive phenomenon and should be considered a cutaneous marker of systemic disease, including underlying malignancy. We present a case of a 56-year-old woman who presented with vague abdominal symptoms and a tender, erythematous rash on her extremities. Biopsy of her skin lesions revealed Sweet's syndrome. A work-up for malignancy eventually demonstrated a pelvic mass and carcinomatosis, and a diagnosis of advanced-stage papillary serous ovarian carcinoma was subsequently made. In postmenopausal women who present with Sweet's syndrome, a comprehensive evaluation for malignancy is indicated. In women with a known diagnosis of cancer, Sweet's syndrome may manifest in the detection of persistent or recurrent disease.