Drug Rash with Eosinophilia and Systemic Symptoms Syndrome in a Patient on Sulfasalazine for Ulcerative Colitis.
- Author:
Kyung Hwan KANG
1
;
Chang Kyun LEE
;
Hyo Jong KIM
;
Jaejun SHIM
;
Jae Young JANG
;
Seok Ho DONG
;
Byung Ho KIM
;
Young Woon CHANG
Author Information
- Publication Type:Case Report
- Keywords: Drug Eruptions; Hypersensitivity; Sulfasalazine; Human Herpes Virus; Ulcerative Colitis
- MeSH: Acetylation; Colitis, Ulcerative; Drug Eruptions; Eosinophilia; Exanthema; Fever; Humans; Hypersensitivity; Inflammatory Bowel Diseases; Latency Period (Psychology); Lymphatic Diseases; Sulfasalazine; Ulcer; Young Adult
- From:Intestinal Research 2012;10(4):383-387
- CountryRepublic of Korea
- Language:English
- Abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening systemic drug reaction characterized by fever, rash, hematological abnormalities, lymphadenopathy, and multiple internal organ involvement. Unfortunately, a long latency period as well as clinicians' unawareness of the disease entity often results in a delay of prompt diagnosis and treatment in clinical practice. A search of the literature revealed only few reports on DRESS in patients with inflammatory bowel diseases. The pathogenesis of the disease is not clearly understood, although several possible mechanisms, such as drug detoxification, slow acetylation, and reactivation of human herpes viruses, have been proposed in its development. Here, we present a rare case of DRESS associated with viral reactivation and defects in drug metabolism in a 22-year-old man who had been on sulfasalazine for 6 weeks to treat ulcerative colitis.
