Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study.
10.3349/ymj.2017.58.6.1111
- Author:
Dirga Kumar LAMICHHANE
1
;
Hwan Cheol KIM
;
Chang Min CHOI
;
Myung Hee SHIN
;
Young Mog SHIM
;
Jong Han LEEM
;
Jeong Seon RYU
;
Hae Seong NAM
;
Sung Min PARK
Author Information
1. Department of Social and Preventive Medicine, Inha University School of Medicine, Incheon, Korea. carpediem@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Air pollution;
lung cancer;
Korea
- MeSH:
Adenocarcinoma;
Air Pollution*;
Carcinoma, Small Cell;
Case-Control Studies*;
Education;
Epithelial Cells;
Fruit;
Humans;
Incidence;
Korea;
Logistic Models;
Lung Neoplasms*;
Lung*;
Nitrogen Dioxide;
Odds Ratio;
Particulate Matter;
Smoke;
Smoking
- From:Yonsei Medical Journal
2017;58(6):1111-1118
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the association between long-term exposure to ambient air pollution and lung cancer incidence in Koreans. MATERIALS AND METHODS: This was a population-based case-control study covering 908 lung cancer patients and 908 controls selected from a random sample of people within each Korean province and matched according to age, sex, and smoking status. We developed land-use regression models to estimate annual residential exposure to particulate matter (PM₁₀) and nitrogen dioxide (NO₂) over a 20-year exposure period. Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI). RESULTS: Increases in lung cancer incidence (expressed as adjusted OR) were 1.09 (95% CI: 0.96−1.23) with a ten-unit increase in PM₁₀ (µg/m³) and 1.10 (95% CI: 1.00−1.22) with a ten-unit increase in NO₂ (ppb). Tendencies for stronger associations between air pollution and lung cancer incidence were noted among never smokers, among those with low fruit consumption, and among those with a higher education level. Air pollution was more strongly associated with squamous cell and small cell carcinomas than with adenocarcinoma of the lung. CONCLUSION: This study provides evidence that PM₁₀ and NO₂ contribute to lung cancer incidence in Korea.
