Gender Difference in the Long-Term Clinical Implications of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting.
10.3349/ymj.2017.58.6.1119
- Author:
Seung Hyun LEE
1
;
Hancheol LEE
;
Jin Kyu PARK
;
Jae Sun UHM
;
Jong Youn KIM
;
Hui Nam PAK
;
Moon Hyoung LEE
;
Ho Geun YOON
;
Boyoung JOUNG
Author Information
1. Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. cby6908@yuhs.ac
- Publication Type:Original Article
- Keywords:
Atrial fibrillation;
coronary artery bypass graft;
postoperative complications;
survival;
gender
- MeSH:
Atrial Fibrillation*;
Coronary Artery Bypass*;
Coronary Vessels*;
Female;
Follow-Up Studies;
Humans;
Male;
Mortality;
Multivariate Analysis;
Postoperative Complications;
Propensity Score;
Transplants
- From:Yonsei Medical Journal
2017;58(6):1119-1127
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG) surgery. This study evaluated gender differences in the long-term clinical implications of POAF. MATERIALS AND METHODS: After propensity score matching, a gender-based comparison of long-term (>1 year) newly developed atrial fibrillation (LTAF) and mortality between 1664 (480 females) consecutive patients with (POAF) and without POAF (no-POAF) who had undergone CABG was performed. RESULTS: During a follow-up of 49±28 months, cumulative survival free of LTAF was lower in the POAF group than in the no-POAF group for both males (92.1% vs. 98.2%, p<0.001) and females (84.1% vs. 98.0%, p<0.001). However, female patients with POAF more frequently developed LTAF than male POAF patients (13.9 % vs. 6.9%, p=0.049). In multivariate analysis, POAF was a significant predictor of LTAF among males [hazard ratio (HR) 4.91; 95% confidence interval (CI) 1.22–19.79, p=0.031] and females (HR 16.50; 95% CI 4.79–56.78; p<0.001). POAF was a predictor of long-term mortality among females (adjusted HR 3.96; 95% CI 1.13–13.87, p=0.033), but not among males. CONCLUSION: Although POAF was related to LTAF in both genders, cumulative survival free of LTAF was poorer among females than among males. Additionally, a significant correlation with long-term mortality after CABG was observed among female patients with POAF.
