Herpes Simplex Esophagitis: A report of two cases.
- Author:
Eun Ha JUNG
;
Hae Kyung AHN
;
Jin Hee SOHN
- Publication Type:Case Report
- Keywords:
Herpes simplex virus;
Esophagitis
- MeSH:
Acyclovir;
Biopsy;
Drug Therapy;
Eosinophils;
Epithelial Cells;
Esophagitis*;
Exudates and Transudates;
Herpes Simplex*;
Humans;
Mucous Membrane;
Opportunistic Infections;
Peptic Ulcer;
Polymerase Chain Reaction;
Simplexvirus
- From:Korean Journal of Pathology
1999;33(4):288-291
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Herpes simplex esophagitis has been recognized with increased frequency as an opportunistic infection in immunosuppressed or debilitated patients. However, it is also documented as self-limited esophagitis in apparently healthy patients. We report two cases of herpetic esophagitis diagnosed by biopsies. One case was noted in an immunocompetent patient having gastric peptic ulcer who had clinical improvement with symptomatic treatment. And the other was noted in an immunosuppressed patient having chemotherapy for gastric carcinoma who had resolution of symptoms with acyclovir therapy. Histologically, esophageal mucosa exhibited erosion and inflammatory cellular exudate with intranuclear eosinophilic inclusions in the epithelial cells. These were confirmed by the PCR and immunohistochemical stain for herpes simplex virus using a biopsy material.
