A Gender-Specific Association between Self-Reported Snoring and Hemoglobin A1c Levels in a General Population without Type 2 Diabetes Mellitus.
10.3349/ymj.2017.58.6.1152
- Author:
Young Hoon LEE
1
;
Sun Seog KWEON
;
Jin Su CHOI
;
Hae Sung NAM
;
Kyeong Soo PARK
;
Seong Woo CHOI
;
Su Hyun OH
;
Sun A KIM
;
Min Ho SHIN
Author Information
1. Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
- Publication Type:Original Article
- Keywords:
Snoring;
hemoglobin A;
glycosylated;
insulin resistance;
gender
- MeSH:
Blood Glucose;
Diabetes Mellitus, Type 2*;
Fasting;
Female;
Hemoglobin A;
Humans;
Insulin;
Insulin Resistance;
Jeollabuk-do;
Male;
Odds Ratio;
Snoring*;
Surveys and Questionnaires
- From:Yonsei Medical Journal
2017;58(6):1152-1159
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We explored whether a gender difference was evident in terms of the associations of snoring with hemoglobin A1c (HbA1c) and homeostatic model assessment-insulin resistance (HOMA-IR) levels in a healthy population without type 2 diabetes mellitus (DM). MATERIALS AND METHODS: We analyzed 2706 males and 4080 females who participated in the baseline survey of the Namwon Study. In terms of self-reported snoring frequency, participants were classified as non-snorers or occasional (1–3 days/week), frequent (4–6 days/week), or constant (7 days/week) snorers. Participants with DM, defined as a fasting blood glucose level ≥126 mg/dL and/or use of insulin or hypoglycemic medication, were excluded from the analysis. RESULTS: In females, the fully adjusted mean (95% confidence interval) HbA1c levels in non-snorers and in occasional, frequent, and constant snorers were 5.53% (5.47–5.59%), 5.53% (5.47–5.59%), 5.57% (5.49–5.64%), and 5.57% (5.51–5.64%), respectively, reflecting a dose-response relationship (p trend=0.004). Compared with female non-snorers, the risk of an elevated HbA1c level (top quintile, ≥5.9%) in constant snorers remained significant (odds ratio 1.30, 95% confidence interval 1.02–1.66) after full adjustment. In addition, in females, a significant linear trend in HbA1c level odds ratio by increased snoring frequency was apparent (p trend=0.019 in model 3). In contrast, no significant association between snoring frequency and HbA1c level was identified in males. No significant association between snoring frequency and HOMA-IR was detected in either gender. CONCLUSION: We discovered a gender-specific association between snoring and HbA1c level in a healthy, community-dwelling population free of DM.
