A Case Report of Anaphylactoid Reaction for Thiopental.
10.4097/kjae.1993.26.5.1046
- Author:
Young Jin LIM
1
;
Hong Seuk YANG
Author Information
1. Department of Anesthesiology, Chung-Ang University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Anaphylactic reaction;
thiopental sodium
- MeSH:
Adult;
Anaphylaxis;
Basophils;
Bronchial Spasm;
Edema;
Erythema;
Histamine;
Humans;
Hypotension;
Incidence;
Male;
Mast Cells;
Sodium;
Thiopental*;
Thrombophlebitis
- From:Korean Journal of Anesthesiology
1993;26(5):1046-1050
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sodium thiopental is a popular intravenous anesthetic that has been used extensively throughout the world. The rare adverse reactions to thiopental consist mainly of anaphylactic shock, bronchospasm, and local thrombophlebitis. The reported incidence of presumed anaphylactic reaction (Type l hypersensitivity) to thiopental are extremely rare. Although the mechanism of these adverse reactiona is unclear, the clinical features (generalized erythema, hypotension, edema and bronchspasm) are thought to result from massive discharge of histamine and other vasoactive substance from basophils and mast cells. Since such reactions are life threatening, they must be recognized immediately and the appmpriate treatment given. The successful management of anaphylaxis requires a thorough understanding of this syndrome and the application of therapeutic agents. The authors report a case of anaphylactoid response to thiopental in a 34 years old healthy male patient and briefly review the literature.
