Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits.
10.5051/jpis.2017.47.2.86
- Author:
Myung Jae JOO
1
;
Jae Kook CHA
;
Hyun Chang LIM
;
Seong Ho CHOI
;
Ui Won JUNG
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. drjew@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone substitutes;
Collagen;
Dental implants;
Recombinant human bone morphogenetic protein-2;
Sinus floor augmentation
- MeSH:
Bone Substitutes*;
Collagen;
Dental Implants;
Humans;
Maxillary Sinus;
Osseointegration;
Rabbits*;
Sinus Floor Augmentation;
Transplants
- From:Journal of Periodontal & Implant Science
2017;47(2):86-95
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. METHODS: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. RESULTS: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). CONCLUSIONS: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.
