Gastric mucosal immune response of Helicobacter pylori-infected children.
10.3345/kjp.2008.51.5.492
- Author:
Hye Won YOM
1
;
Jeong Wan SEO
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. jwseo@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Children;
Gastric mucosa;
Lymphocyte subsets
- MeSH:
B-Lymphocytes;
Biopsy;
Carbamates;
Child;
Endoscopy;
Epithelium;
Gastric Mucosa;
Gastritis;
Helicobacter;
Helicobacter pylori;
Humans;
Immunity, Mucosal;
Immunohistochemistry;
Lymphocyte Subsets;
Lymphocytes;
Mucous Membrane;
Organometallic Compounds;
Peptic Ulcer;
T-Lymphocytes;
Tobacco
- From:Korean Journal of Pediatrics
2008;51(5):492-499
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose: Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal immune response against H. pylori in clinically well-defined groups: H. pylori-positive (divided into peptic ulcer disease and gastritis) and H. pylori-negative control. Methods: Antral biopsies were obtained from 45 children undergoing an upper GI endoscopy for dyspeptic symptoms. T cells (CD3+, CD4+, CD8+) and B cells (CD20+) were analyzed by quantitative immunohistochemistry. The correlation of lymphocyte subsets of gastric mucosa with histology was evaluated. Results: T cells (CD3+, CD4+, CD8+) and B cells (CD20+) were significantly increased in the lamina propria of H. pylori-positive group (p<0.01). CD8+ T cells were significantly increased in the lamina propria of the H. pylori-positive peptic ulcer disease (p<0.01). Within the epithelium, only CD4+ T cells were significantly increased in the H. pylori-positive group (p<0.01). Gastric histological parameters had a closer correlation with lymphocytes in the lamina propria than intraepithelial lymphocytes. Conclusion: This study suggests that both T cells and B cells in the lamina propria play important roles in the local immune response of H. pylori-infected children. Furthermore, it remains to be elucidated whether CD8+ T cells in the lamina propria may contribute to peptic ulcer formation in H. pylori-infected children.
