The Association between Asthma and Invasive Pneumococcal Disease: A Nationwide Study in Korea.
10.3346/jkms.2015.30.1.60
- Author:
Byung Ok KWAK
1
;
Ji Tae CHOUNG
;
Yong Mean PARK
Author Information
1. Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea. pymcko@marathoner.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Asthma;
Invasive Pneumococcal Disease;
Diabetes Mellitus
- MeSH:
Adolescent;
Adult;
Aged;
Asthma/complications/*epidemiology;
Child;
Cohort Studies;
Diabetes Mellitus/epidemiology;
Heptavalent Pneumococcal Conjugate Vaccine/immunology;
Humans;
Immunologic Deficiency Syndromes/complications/*epidemiology;
Middle Aged;
Pneumococcal Infections/complications/*epidemiology;
Pneumococcal Vaccines/immunology;
Prevalence;
Republic of Korea/epidemiology;
Retrospective Studies;
Streptococcus pneumoniae/pathogenicity;
Young Adult
- From:Journal of Korean Medical Science
2015;30(1):60-65
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate the association between asthma and invasive pneumococcal disease (IPD) in Korea. A retrospective population-based cohort study was conducted using the Korean Health Insurance Review and Assessment database 2010-2011. The subjects included 935,106 (2010) and 952,295 (2011), of whom 398 (2010) and 428 (2011) patients with IPD were identified. There was significant difference in the prevalence of IPD in patients with and without asthma (0.07% vs. 0.02% in 2010 and 0.08% vs. 0.01% in 2011; P<0.001). After adjusting for age and gender, patients with asthma showed over a three-fold increased risk of IPD compared with patients without asthma (adjusted odds ratio [aOR] 3.90, 95% confidence interval [CI] 3.02-5.03 in 2010 / aOR, 5.44; 95% CI, 4.10-7.22 in 2011; P<0.001). These findings were also significant in children (aOR, 2.08; 95% CI, 1.25-3.45 in 2010; P=0.005 / aOR, 3.26; 95% CI, 1.74-6.11 in 2011; P<0.001). Although diabetes mellitus was also significantly associated with IPD, relatively low ORs compared with those of asthma were noted (aOR, 1.85; 95% CI, 1.35-2.54 in 2010 / aOR, 2.40; 95% CI, 1.78-3.24 in 2011; P<0.001). Both children and adults with asthma are at increased risk of developing IPD.
