Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report.
10.3346/jkms.2015.30.1.110
- Author:
Hee Jin KWON
1
;
Kwai Han YOO
;
In Young KIM
;
Seulkee LEE
;
Hye Ryoun JANG
;
Ghee Young KWON
Author Information
1. Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Acute Kidney Injury;
Megalocytic Interstitial Nephritis;
Interstitial Nephritis
- MeSH:
Acute Disease;
Acute Kidney Injury/complications/*drug therapy/pathology;
Anti-Bacterial Agents/therapeutic use;
Azithromycin/therapeutic use;
Bacteremia/*drug therapy/microbiology/pathology;
Cefotaxime/therapeutic use;
Creatinine/blood;
Escherichia coli;
Escherichia coli Infections/*drug therapy/microbiology/pathology;
Female;
Humans;
Kidney/pathology;
Methylprednisolone/therapeutic use;
Middle Aged;
Nephritis, Interstitial/*drug therapy/immunology/pathology;
Pyelonephritis/complications/*drug therapy/pathology;
Renal Dialysis;
Shock, Septic/drug therapy/microbiology
- From:Journal of Korean Medical Science
2015;30(1):110-114
- CountryRepublic of Korea
- Language:English
-
Abstract:
Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.
