A Case of Vancomycin-Induced Linear IgA Bullous Dermatosis.
- Author:
Ki Seung DOH
1
;
Sung Hee KIM
;
Tae Sik CHOI
;
Min Soo JANG
;
Kee Suck SUH
;
Sang Tae KIM
Author Information
1. Department of dermatology, Kosin Medical College, Busan, Korea. ksderm98@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Vancomycin;
Linear IgA bullous dermatosis
- MeSH:
Aged;
Basement Membrane;
Biopsy;
Blister;
Dapsone;
Eosinophils;
Fluorescent Antibody Technique, Direct;
Foot;
Genitalia;
Humans;
Immunoglobulin A;
Knee;
Korea;
Linear IgA Bullous Dermatosis*;
Male;
Microscopy;
Neutrophils;
Skin;
Staphylococcus aureus;
Teicoplanin;
Vancomycin
- From:Korean Journal of Dermatology
2002;40(9):1132-1135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Linear IgA bullous dermatosis(LAD) is a subepidermal blistering disease characterized by linear IgA deposits in the basement membrane zone when visualized on direct immunofluorescence microscopy. Intravenous vancomycin has been the drug most implicated, and this disease has been termed vancomycin-induced LAD. Vancomycin-induced LAD tends to spontaneously resolve upon discontinuation of the offending drug. A 70-year-old male patient developed septic knee. Bacterial cultures from this lesion grew methicillin- resistant Staphylococcus aureus. He was treated with vancomycin. Eight days after vancomycin injection, painful bullae appeared on the trunk, feet, and genitalia. A skin biopsy showed a subepidermal blister with an infiltrate composed of neutrophils and eosinophils. Direct immunofluorescence of perilesional skin showed linear IgA deposition at dermo-epidermal junction. The vancomycin was stopped; teicoplanin was substituted. He was treated with dapsone. The use of vancomycin is increasing in Korea and therefore it is important for dermatologist to be aware of the association with LAD.
