Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry.
10.3803/EnM.2016.31.4.598
- Author:
Seung Jin HAN
1
;
Kyung Soo KIM
;
Wonjin KIM
;
Jung Hee KIM
;
Yong ho LEE
;
Ji Sun NAM
;
Ji A SEO
;
Bu Kyung KIM
;
Jihyun LEE
;
Jin Ook CHUNG
;
Min Hee KIM
;
Tae Seo SOHN
;
Han Seok CHOI
;
Seong Bin HONG
;
Yoon Sok CHUNG
Author Information
1. Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea. yschung@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Klinefelter syndrome;
Obesity;
Hyperglycemia
- MeSH:
Blood Pressure;
Dyslipidemias;
Fasting;
Follicle Stimulating Hormone;
Glucose;
Hospitals, University;
Humans;
Hyperglycemia*;
Hypertension;
Hypogonadism;
Karyotyping;
Klinefelter Syndrome*;
Korea;
Luteinizing Hormone;
Male;
Medical Records;
Obesity*;
Prevalence;
Retrospective Studies;
Risk Factors;
Testosterone
- From:Endocrinology and Metabolism
2016;31(4):598-603
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to investigate the prevalence of obesity in Korean men with Klinefelter syndrome (KS) and the associated risk factors for obesity and hyperglycemia. METHODS: Data were collected retrospectively from medical records from 11 university hospitals in Korea between 1994 and 2014. Subjects aged ≥18 years with newly diagnosed KS were enrolled. The following parameters were recorded at baseline before treatment: chief complaint, height, weight, fasting glucose level, lipid panel, blood pressure, testosterone, luteinizing hormone, follicle-stimulating hormone, karyotyping patterns, and history of hypertension, diabetes, and dyslipidemia. RESULTS: Data were analyzed from 376 of 544 initially enrolled patients. The rate of the 47 XXY chromosomal pattern was 94.1%. The prevalence of obesity (body mass index ≥25 kg/m²) in Korean men with KS was 42.6%. The testosterone level was an independent risk factor for obesity and hyperglycemia. CONCLUSION: Obesity is common in Korean men with KS. Hypogonadism in patients with KS was associated with obesity and hyperglycemia.
