Infusion-Related Toxicities of DMSO Containing Cryopreserved Blood.
- Author:
Byung Soo KIM
1
;
In Kun CHOI
;
Suk Jin KIM
;
Chae Seung LIM
;
Jae Hong SEO
;
Chul Won CHOI
;
Sang Won SHIN
;
Yeul Hong KIM
;
Kap No LEE
;
Jun Suk KIM
Author Information
1. Department of Internal Medicine and Clinical Pathology*, Korea University, School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Dimethyl-sulfoxide;
Infusion-related toxicity
- MeSH:
Blood Platelets;
Bone Marrow;
Death, Sudden;
Dimethyl Sulfoxide*;
Dyspnea;
Hematopoietic Stem Cells;
Hematuria;
Humans;
Incidence;
Nausea;
Retrospective Studies;
Seizures;
Sensation;
Vomiting
- From:Korean Journal of Blood Transfusion
1998;9(1):51-57
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We retrospectively evaluated infusion-related toxicities in the patients transfused with frozen-thawed blood mixed with dimethyl-sulfoxide (DMSO). METHODS: The incidence and severity of infusion-related toxicities in the 25 patients transfused with frozen-thawed blood containing hematopoietic stem cells mixed with 10% DMSO were compaired with those of other 18 patients (11 patients;transfused with ABO-compatible allogeneic marrow blood without DMSO, 7 patients;transfused with platelet concentrates which were frozen with 6% DMSO and washed after thawing to remove DMSO). RESULT: The median transfusion volume of blood containing DMSO was 280cc and that of blood without DMSO was 180cc. The infusion-related toxicities of blood containing DMSO were nausea (96%, 24/25), febrile sensation (88%, 22/25), vomiting (48%, 12/25), hematuria (32%, 8/25), dyspnea (16%, 4/25), convulsion (8%, 2/25), and sudden death (4%, 1/25). That of blood without DMSO was febrile sensation (5.6%, 1/18). The incidence of infusion-related toxicities of blood containing DMSO was significantly higher than that of blood without DMSO (p<0.05). CONCLUSION: It could be suggestive that the infusion-related toxicities of blood containing DMSO was occured more frequently and severely than those of blood without DMSO.
