Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus.
- Author:
Jin Soon HWANG
1
;
Sei Won YANG
Author Information
1. Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Type 1 diabetes mellitus;
Honeymoon period;
Insulin
- MeSH:
Autoimmune Diseases;
Blood Glucose;
C-Peptide;
Child*;
Diabetes Mellitus*;
Diabetes Mellitus, Type 1;
Diabetic Ketoacidosis;
Diagnosis;
Glucose;
Humans;
Insulin
- From:Journal of the Korean Pediatric Society
2000;43(8):1106-1110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic beta-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic beta-cell function. The aim of this study was to determine factors influencing the onset of honeyrnoon period in children with type I DM. METHODS: The study group was composed of 50 patients with type I DM. The honeymoon period was defined as a period requiring less than 0.5U/kg/day to maintain near-normal blood glucose control without urine glucose for consecutive days. The factors for three study were age at diagnosis, sex, initial 24-hr urine C-peptide, initial HbA C, diabetic ketoacidosis and maximum insulin dose for near-normal blood glucose control before honeymoon. RESULTS: The group with honeymoon period received significantly smaller doses of insulin near-normal blood glucose control, compared to the group without honeymoon period, before honeymoon(P<0.01). Other factors had no significant connection with the development of honeymoon period. CONCLUSION: The developrnent of honeymoon period in type I DM had a significant relationship with maximum insulin dose before the onset of honeymoon period for near-normal blood glucose control. This needs remains to be further study.
