A Case of Primary Multiple Intracerebral spergillosis Abscess in Neonate:Treatment with Amphotericin B, Flucytosine and Itraconazole.
- Author:
Byoung Lae OH
1
;
Oh Kyung LEE
;
Yong Seog KIM
;
Young Sook KIM
Author Information
1. Department of Pediatrics, Presbyterian Medical Center, Chonju, Korea.
- Publication Type:Case Report
- Keywords:
Brain abscess;
Aspergillus;
Amphotericin B;
Flucytosine;
Itraconazole
- MeSH:
Abscess*;
Amphotericin B*;
Aneurysm;
Aspergillosis;
Aspergillus;
Azotemia;
Brain;
Brain Abscess;
Central Nervous System;
Child;
Dehydration;
Flucytosine*;
Granulomatous Disease, Chronic;
Hematologic Neoplasms;
Humans;
Immunocompromised Host;
Infant, Newborn;
Intracranial Hemorrhages;
Itraconazole*;
Magnetic Resonance Imaging;
Meningitis;
Meningoencephalitis;
Survivors;
Vasculitis
- From:Journal of the Korean Pediatric Society
2000;43(8):1116-1121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fungal infection of the central nervous system tends to occur mostly in immunosuppressed patients. In the pediatric population, it is usually seen in severely immunocompromised patients, particulary in children with chronic granulomatous disease and hematopoietic malignancies. Although aspergillosis is considered one of the most frequent agents of mycotic infection of the brain, it is especially rare in the neonatal period, and overwhelming multisystem infection is usually diagnosed postmortem. Manifestations include meningitis, meningoencephalitis, granulomata formation, brain abscess, vasculitis, aneurysm formation, infarct and intracranial hemorrhage. We present a neonate who had brain abscess diagnosed by MRI, and aspergillus was found at surgical exploration. There are very few reported survivors of neonatal aspergillosis. We reported a case of primary multiple brain abscess caused by aspergillus associated with severe hypernatremic dehydration and prerenal azotemia. The patient was treated with amphotericin B combined with flucytosine and itraconazole.
