Clinical Evaluation of Tc-99m Ciprofloxacin for the Diagnosis of Infectious Disease.
- Author:
In Gyu BAE
1
;
Sun Young CHOI
;
Yang Soo KIM
;
Mi Suk LEE
;
Seung Jun OH
;
Jin Suk RYU
;
Ji So RYU
;
Hee Kyung LEE
;
Jun Hee WOO
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Infection;
Tc-99m ciprofloxacin;
Infective spondylitis
- MeSH:
Bacterial Infections;
Ciprofloxacin*;
Communicable Diseases*;
Diagnosis*;
Humans;
Inflammation;
Leukocytes;
Sensitivity and Specificity;
Skeleton;
Spondylitis;
Technetium Tc 99m Exametazime
- From:Korean Journal of Infectious Diseases
2001;33(2):128-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: For the evaluation of infectious or inflammatory disease, Tc-99m HMPAO WBC scan has been used. But techniques involving radiolabelled leukocytes scan were difficult, and have failed to distinguish between bacterial infection and non-bacterial inflammation. To overcome this difficulty, we evaluated Tc-99m Ciprofloxacin in clinically suspected bacterial infection. METHODS: We used this agent for 31 patients who had suspected sites of infection. And then we compared the imaging results of these patients with those of radiolabelled leukocyte scan. RESULTS: There was no adverse effect. 29 patients was involved for the interpretation. Infective spondylitis was the most common suspected disease (41%). Bateriologic culture was positive in 10 patients. The most common organism was meticillin-susceptible S. aureus (5 cases). The sensitivity and specificity of Tc- 99m Ciprofloxacin was 83.3% and 66.6%, and those of Tc-99m HMPAO WBC was 62.5% and 83.3%, repectively. For the diagnosis of infective spondylitis the sensitivity of Tc-99m Ciprofloxacin was 80.0% and that of Tc-99m HMPAO WBC was 40.0%. CONCLUSOIN: Tc-99m Ciprofloxacin shows relatively high sensitivity and specificity. Tc-99m Ciprofloxacin was superior to Tc-99m HMPAO WBC for the diagnosis of infection in axial skeleton.
