Endoscopic Photodynamic Diagnosis (PDD) Using Oral 5-aminolevulinic Acid in Gastrointestinal Cancer and Dysplastic Lesions.
- Author:
Young Koog CHEON
1
;
Young Deok CHO
;
Jin Oh KIM
;
Joo Yong CHO
;
Joon Seong LEE
;
Yun Soo KIM
;
Moon Sung LEE
;
Chan Sup SHIM
Author Information
1. Digestive Disease Center, Institute for Digestive Research, Soon Chun Hyang University College of Medicine, Seoul, Korea. schidr@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Gastrointestinal cancer;
Dysplasia;
Photosensitizer;
5-aminolevulinic acid;
Photodynamic diagnosis
- MeSH:
Adenoma;
Administration, Oral;
Bile Duct Neoplasms;
Diagnosis*;
Fluorescence;
Gastrointestinal Neoplasms*;
Gastrointestinal Tract;
Humans;
Mass Screening;
Selection Bias;
Stomach Neoplasms
- From:Korean Journal of Gastrointestinal Endoscopy
2003;26(2):73-78
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIM: Endoscopic screening for the detection of premalignant high-grade dysplasia remains time consuming and is subject to sampling error. We performed this study to determine the clinical usefulness of laser endoscopic spectra analyzer (LESA-7) in gastrointestinal cancer and dysplastic lesions. METHODS: Seventeen patients with histologically proven carcinoma or adenoma with or without high-grade dysplasia were treated with oral administration of 5-ALA (20 mg/kg). PDD was performed 4 hours later. The fluorescence was excited by a helium-neon laser with emission at 637 nm. The generated fluorescence light was collected and fed into a multi-channel analyzer and the full spectrum was displayed in real time (LESA-7). RESULTS: In most of malignant tumors, a clear protoporphyrin IX-related dual-peaked fluorescence signal at about 635 and 700 nm was identified in the fluorescence spectra. However, it was not fully identified in bile duct cancers. In PDD of post-EMR in order to detect residual lesions (gastric flat adenoma 1, early gastric cancer 2), a dual spectra was not identified. CONCLUSIONS: PDD with 5-ALA might be useful for the detection of dysplasia and carcinoma in the gastrointestinal tract.
