A Case of Malignant B-Cell Lymphoma Involving the Stomach in a Patient with Neurofibromatosis Type 1.
- Author:
Dok Yong LEE
1
;
Jun Pyo CHUNG
;
Sang Won JI
;
Jung Hwan KIM
;
Jong Kwan PARK
;
Se Joon LEE
;
Byoung Soo MOON
;
Kwan Sik LEE
;
Sang In LEE
;
Eun Ah SHIN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. chungjp@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Malignant lymphoma;
Neurofibromatosis type 1;
Stomach
- MeSH:
Aged;
B-Lymphocytes*;
Cafe-au-Lait Spots;
Diagnosis;
Diagnosis, Differential;
Endoscopy, Digestive System;
Female;
Humans;
Korea;
Leukemia;
Lung Neoplasms;
Lymphoma;
Lymphoma, B-Cell*;
Neurofibroma;
Neurofibromatoses*;
Neurofibromatosis 1*;
Neurofibrosarcoma;
Pheochromocytoma;
Stomach*
- From:Korean Journal of Gastrointestinal Endoscopy
2003;26(2):90-93
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neurofibromatosis type 1, an autosomal dominant disorder, is clinically characterized by the presence of cafe-au-lait spots and cutaneous neurofibromas. Malignancy is a frequently cited and feared complication of neurofibromatosis. Neurofibromatosis has been reported to be associated with some CNS tumors, neurofibrosarcoma, pheochromocytoma, and nonlymphocytic leukemia. Also malignant lymphoma may develop in patients with neurofibromatosis. In Korea, only a case of lung cancer and a case of pheochromocytoma have been reported to develop in patients with neurofibromatosis type 1. Recently, we experienced a case of malignant lymphoma involving the stomach in a 70-year-old woman with neurofibromatosis type 1. An esophagogastroduodenoscopy revealed a 5 cm sized ulcerofungating mass on the greater curvature of the upper body. Histologic diagnosis of the biopsied specimen was B-cell diffuse small and large cell lymphoma. This case illustrates that malignant lymphoma should be included in the differential diagnosis of gastric tumors in patients with neurofibromatosis type 1.
