The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease.
- Author:
Hyo Jin LEE
1
;
Myung Sook LEE
;
Ji Sook KIM
;
Eun Ryoung KIM
;
Sung Wook KANG
;
Soo Kang KIM
;
Joo Ho CHUNG
;
Kyung Lim YOON
;
Mi Young HAN
;
Seong Ho CHA
Author Information
- Publication Type:Original Article
- Keywords: Mucocutaneous lymph node syndrome; Kawasaki disease; Coronary artery disease; Genetic polymorphism; Catechol-O-Methyltransferase
- MeSH: Catechol O-Methyltransferase; Catecholamines; Catechols; Child; Coronary Artery Disease; Coronary Vessels; Estrogens; Genotype; Humans; Mucocutaneous Lymph Node Syndrome; Myocardial Infarction; Polymorphism, Genetic
- From:Korean Journal of Pediatrics 2009;52(1):87-92
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O-methyltransfe rase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients. METHODS: One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing. RESULTS: There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patie nts with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.0077, dominant P=0.0021, recessive P=0.16). CONCLUSION: Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
