A Case of Salicylate-Intoxication-Induced Pseudohyperchloremia.
10.3904/kjm.2015.89.4.457
- Author:
Hyo Jong KIM
1
;
You Jeong OH
;
Jeong Seok LEE
;
Sang Yu OH
;
Jong Yoon LEE
Author Information
1. Department of Internal Medicine, Dong-Eui Hospital, Dong-Eui University College of Oriental Medicine, Busan, Korea. hig717@naver.com
- Publication Type:Case Report
- Keywords:
Salycylate intoxication;
Pseudohyperchloremia;
Hemodialysis
- MeSH:
Acid-Base Equilibrium;
Acidosis;
Aged, 80 and over;
Analgesics;
Aspirin;
Female;
Humans;
Korea;
Mortality;
Poisoning;
Renal Dialysis
- From:Korean Journal of Medicine
2015;89(4):457-460
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Despite the increasing use of alternative analgesic agents, salicylate overdose remains a not-uncommon problem. Severe poisoning is life threatening, so prompt treatment and supportive measures are required to reduce mortality. Generally, salicylate intoxication results in the development of high-anion-gap metabolic acidosis. However, outside of Korea, normal-anion-gap or negative-anion-gap metabolic acidosis with hyperchloremia is rarely reported. We report herein the case of an 83-year-old female patient with chronic aspirin intake who presented with hyperchloremia and a negative anion gap. The patient's symptoms improved with conservative treatment and hemodialysis; notably, her chloride levels decreased as her blood salicylate concentrations decreased. Salicylate may cause hyperchloremia, demonstrating the importance of careful documentation of patient medication histories.
