Distal Renal Tubular Acidosis Caused by Tacrolimus in a Systemic Lupus Erythematosus Patient: A Case Report.
10.3904/kjm.2015.89.4.478
- Author:
Hae Koo KIM
1
;
Ji Hyun LEE
;
In Hye KU
;
Sung Min KANG
;
Joon Sul CHOI
;
Sung Jun KIM
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, Korea. ete@lycos.co.kr
- Publication Type:Case Report
- Keywords:
Acidosis, Renal tubular;
Tacrolimus;
Lupus erythematosus, Systemic
- MeSH:
Acid-Base Equilibrium;
Acidosis;
Acidosis, Renal Tubular*;
Anemia, Sickle Cell;
Arthritis, Rheumatoid;
Autoimmune Diseases;
Fibrosis;
Humans;
Hydrogen;
Kidney Transplantation;
Lupus Erythematosus, Systemic*;
Muscle Weakness;
Paralysis;
Potassium;
Sjogren's Syndrome;
Tacrolimus*
- From:Korean Journal of Medicine
2015;89(4):478-481
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Renal tubular acidosis (RTA) refers to a group of disorders involving transport defects in bicarbonate reabsorption or hydrogen excretion. Features like metabolic acidosis with a normal anion gap, neurological symptoms, and electrolyte imbalances indicate RTA. Kidney transplantation, cirrhosis, sickle cell anemia, medications, and autoimmune diseases, particularly Sjogren's syndrome and rheumatoid arthritis, are related to RTA. We encountered a rare case of a patient with systemic lupus erythematosus accompanied by RTA secondary to tacrolimus administration, who had muscle weakness and paralysis. Her symptoms improved after discontinuing tacrolimus and correcting the acidosis and potassium levels. Here, we report on this case and review the relevant literature.
