Uric Acid Is a Risk Indicator for Metabolic Syndrome-related Colorectal Adenoma: Results in a Korean Population Receiving Screening Colonoscopy.
10.4166/kjg.2015.66.4.202
- Author:
Hyo Jin KIM
1
;
Jee Eun KIM
;
Ji Hye JUNG
;
Eun Ran KIM
;
Sung Noh HONG
;
Dong Kyung CHANG
;
Hee Jung SON
;
Poong Lyul RHEE
;
Jae J KIM
;
Young Ho KIM
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea. younghokim@skku.edu
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Uric acid;
Metabolic syndrome X
- MeSH:
Adenoma/*diagnosis/epidemiology/etiology;
Adult;
Asian Continental Ancestry Group;
Blood Glucose/analysis;
Blood Pressure;
Colonoscopy;
Colorectal Neoplasms/*diagnosis/epidemiology/etiology;
Cross-Sectional Studies;
Female;
Humans;
Logistic Models;
Male;
Metabolic Syndrome X/*diagnosis;
Middle Aged;
Odds Ratio;
Prevalence;
Republic of Korea;
Risk Factors;
Triglycerides/blood;
Uric Acid/*blood/urine;
Waist Circumference
- From:The Korean Journal of Gastroenterology
2015;66(4):202-208
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: An association between serum uric acid and cancer risk has been noted over the past few decades. There is ongoing debate about whether hyperuricemia represents an independent risk factor for colorectal neoplasm. We investigated the association between serum uric acid and prevalence of colorectal adenoma considering numerous confounding factors. METHODS: A cross-sectional study was performed with individuals who underwent a routine health check-up examination, including a screening colonoscopy and blood chemistry. The association between serum uric acid and prevalence of colorectal adenoma was estimated from the results of a logistic regression analysis. RESULTS: Of the 1,066 participants, 402 had colorectal adenoma (37.7%). In univariate models, the prevalence of colorectal adenoma was higher in participants in the fourth quartile uric acid level, compared to those in the first quartile uric acid level (OR, 1.67; 95% CI, 1.17-2.42; p=0.004). However, no significant association was detected between serum uric acid and prevalence of colorectal adenoma in multiple logistic regression analysis. A number of metabolic syndrome components exhibited a strong association with the prevalence of colorectal adenoma in the multivariate model (OR, 3.46 for highest vs. lowest; 95% CI, 1.30-9.20; p=0.021). Moreover, serum uric acid was strongly associated with metabolic syndrome-associated variables, including waist circumference, fasting blood glucose, systolic blood pressure, diastolic blood pressure, triglyceride, and high-density lipoprotein. CONCLUSIONS: Uric acid is not an independent risk factor for colorectal adenoma but is a risk indicator for metabolic syndrome-related colorectal adenoma.
