Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly.
10.3803/EnM.2015.30.3.312
- Author:
Hye Yoon PARK
1
;
In Ryang HWANG
;
Jung Bum SEO
;
Su Won KIM
;
Hyun Ae SEO
;
In Kyu LEE
;
Jung Guk KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jugkim@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Growth hormone receptor exon 3 deletion;
Polymorphism;
Acromegaly;
Body mass index;
Fasting plasma glucose
- MeSH:
Acromegaly*;
Blood Glucose;
Blood Pressure;
Body Mass Index;
Cholesterol, HDL;
Cholesterol, LDL;
DNA;
Exons;
Fasting;
Genotype;
Growth Hormone*;
Humans;
Korea;
Polymerase Chain Reaction;
Receptors, Somatotropin*;
Triglycerides
- From:Endocrinology and Metabolism
2015;30(3):312-317
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea. METHODS: DNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters. RESULTS: No patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (P=0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes. CONCLUSION: The d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters.
