Severe Acneiform Eruption Induced by Cetuximab (Erbitux(R)).
10.3349/ymj.2008.49.5.851
- Author:
Jung Eun LEE
1
;
Sang Ju LEE
;
Hee Jung LEE
;
Ju Hee LEE
;
Kwang Hoon LEE
Author Information
1. Yonsei Star Skin & Laser Clinic, Seoul, Korea. kwanglee@yuhs.ac
- Publication Type:Case Report
- Keywords:
Cetuximab;
acneiform eruption
- MeSH:
Acneiform Eruptions/*chemically induced/pathology;
Antibodies, Monoclonal/*adverse effects/therapeutic use;
Antineoplastic Agents/*adverse effects;
Colorectal Neoplasms/drug therapy/pathology;
Humans;
Liver Neoplasms/drug therapy/secondary;
Male;
Middle Aged
- From:Yonsei Medical Journal
2008;49(5):851-852
- CountryRepublic of Korea
- Language:English
-
Abstract:
Epidermal growth factor has an important role in the regulation of proliferation and differentiation in epidermal keratinocytes, as well as in the survival, angiogenesis and metastasis of cancer cells. Cetuximab is a chimeric monoclonal antibody selective for the epidermal growth factor receptor that induces a broad range of cellular responses that enhance tumor sensitivity to radiotherapy and chemotherapeutic agents. However, it can cause adverse events in the patient including acneiform eruption, asthenia, abdominal pain and nausea/vomiting. We report a case of severe acneiform eruption induced by cetuximab in a 56-year-old man with colorectal cancer and liver metastases.
