Clinical Efficacy and Safety of Intravenous levofloxacin in Patients of Abdominal Operati.
- Author:
Yoon Seok CHAE
1
;
Sub Jin CHOI
;
Jong Hoon LEE
;
Kyung Sik KIM
;
Woo Jung LEE
;
Byong Ro KIM
Author Information
1. Department of Surgery, College of Medicine, Yonsei University, Korea. wjlee@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Levofloxacin;
Quinolone antibiotics
- MeSH:
Anti-Bacterial Agents;
Humans;
Levofloxacin*;
Pancreas;
Staphylococcus
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2001;5(1):169-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: For the investigation of the efficacy and safety of intravenous levofloxacin, The clinical study was carrried out in 30 patients with abdominal operation, especially in hepatobiliary and pancreatic division. METHODS: Randomly chosen patients received intravenous levofloxacin (250mg bid) for only 7 days. Clinical and microbiological evaluation were conducted on the day of starting and finishing levofloxacin treatmeat except for the case of combined use of antibiotics. RESULTS: The most commonly isolated organism was staphylococcus aureus(33%, 3/9). The overall bacteriologic eradication rate was 67%, (6/9) with clinical success rate was 96%(29/30), There were no significant dverse effects to stop the administration of the drug. CONCLUSION: These results suggest that intravenous levofloxacin is effective and safe antibiotics in the fields management of abdominal operation especially in hepatobiliary and pancreas surgery.
