An Association between Apolipoprotein E Genotype and Colonic Adenomas in Korean.
- Author:
Sang Jong PARK
1
;
Hee Jung SON
;
Ji Min LEE
;
Mun Hee BAE
;
Tae Wook KANG
;
Young Ho KIM
;
Yoon Ho CHOI
;
Jae J KIM
;
Poong Lyul RHEE
;
Jong Chul RHEE
;
Bong Joon CHOI
;
Kyoo Wan CHOI
Author Information
1. Devision of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hjson@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Apolipoprotein E;
epsilon4 allele;
Colonic adenoma
- MeSH:
Adenoma*;
Alleles;
Apolipoproteins*;
Bile Acids and Salts;
Cholesterol;
Colon*;
Colonoscopy;
Genotype*;
Heterozygote;
Homozygote;
Humans;
Male;
Mass Screening;
Metabolism;
Polymerase Chain Reaction;
Sigmoidoscopy;
Triglycerides
- From:Korean Journal of Gastrointestinal Endoscopy
2001;23(1):14-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Apolipoprotein E polymorphism plays an important role in the metabolism of cholesterol and bile acids, which may be related to the development of colorectal adenomas. An association between apolipoprotein E genotype and colonic adenomas has been reported in a western country. This study was designed to determine whether the apolipoprotein E was genotype would be associated with proximal or distal colonic adenomas in Koreans. METHODS: On the colonoscopy, colonic adenomas were found in 132 patients. Proximal colonic adenoma was found in 35 patients and distal colonic adenoma was found in 97 patients. Serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride were measured. Apolipoprotein E genotype was determined by PCR and allele specific oligonucleotide hybridization. 279 control subjects without an adenoma on the screening sigmoidoscopy were selected randomly. RESULTS: The serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglyceride did not significantly differ between each adenoma group and control group. The individual frequencies of epsilon2, epsilon3 and epsilon4 alleles in patients with colonic adenomas did not differ from those in control subjects. The frequency of either heterozygote or homozygote for epsilon4 allele in patients with proximal adenoma was lower than that in control subjects (0.029 vs 0.168, p<0.05). CONCLUSIONS: The data suggest that epsilon4 allele may be associated with a lower risk for the development of proximal colonic adenoma in Korean men.
